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KMID : 0366220090440040289
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Korean Journal of Hematology
2009 Volume.44 No. 4 p.289 ~ p.293
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Successful Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndrome with Invasive Fungal Infection - A Case Report -
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Kim Hyun-Su
Kim Se-Hyung
Kim Hyun-Jung
Lee Sang-Cheol
Bae Sang-Byung
Kim Chan-Kyu
Lee Kyu-Taek
Park Sung-Kyu
Won Jong-Ho
Hong Dae-Sik
Park Hee-Sook
Choo Eun-Ju
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Abstract
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Myelodysplastic syndrome (MDS) is a heterogeneous group of disorders characterized by ineffective hematopoiesis, morphological dysplasia, peripheral blood cytopenias, and progressive bone marrow failure. The only proven curative treatment for MDS is hematopoietic stem cell transplantation. However, invasive fungal infection following hematopoietic stem cell transplantation has become the leading cause of death from infection. Therefore, transplant candidates with previous invasive fungal infection have often been excluded from the transplant program due to high risk of reactivation and associated death. We report on a case involving an MDS patient with complications from invasive aspergillosis who had shown no response to amphotericin-B. The patient underwent successfully unrelated allogeneic hematopoietic stem cell transplantation. (Korean J Hematol 2009;44:289-293.)
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KEYWORD
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Myelodysplastic syndrome, Hematopoietic stem cell transplantation, Aspergillosis
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